If the antioxidants in red wine are good for your heart, imagine what they can do for your skin. For those willing to think outside the wine glass, Temecula’s GrapeSeed Spa offers innovative “vine-based” treatments to help you “uncork and unwind.” Cleanse and exfoliate your skin with a grape seed scrub or get your glow on with a Champagne facial that uses the same rare Pinot Noir grape yeast used in the production of Champagne. Nestled amid the sprawling vineyards of South Coast Winery & Resort, the three-story Tuscan-style spa retreat also offers yoga and meditation workshops designed to pamper the inner you. “The GrapeSeed Spa is run on the lines of a holistic spa; a center of nurturing and care,” says spa director Kate Santarsieri. “We are always searching for ways to help people enhance their beauty beyond facials and massage.” And yes, a glass of wine is always included with your treatment. (951/587-9463, www.wineresort.com)   REBECCA CHAPPELL